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HALOS webinar series: Synchrotron light and epigenomics combine to reveal mechanisms of viral chromatin regulation by the Human Silencing Hub (HUSH) complex

Seminar
Welcome to HALOS first webinar in 2021: January 27 at 12 pm.

Speaker: Dr. Christopher Douse

Department of Experimental Medical Science, Lund University

About: The human genome is evolving under constant threat of colonization by infectious retroviruses and transposons. The Human Silencing Hub (HUSH) complex has recently emerged as a central player in the repression of such mobile genetic elements. HUSH regulates deposition of the epigenetic mark H3K9me3 over its targets, and recruits MORC2, an ATPase reported to have chromatin remodelling activity. Patient mutations in MORC2 have been shown to cause severe neuro-developmental disorders. These recent discoveries raise several mechanistic questions. How do HUSH subunits assemble on chromatin? How do HUSH and MORC2 repress their targets? And how does MORC2 mutation misregulate its function to cause human disease? To address these questions we have undertaken a systematic, multi-scale analysis of the structural, biochemical and functional properties of MORC2 and the core HUSH scaffold, TASOR. I will describe our latest model for how this critical protein machinery works to defend the human genome.

Registration

https://webforms.med.lu.se/halos-webinar-december-7/

 

Time: 
27 January 2021 12:00 to 13:00
Location: 
Online/zoom
Contact: 
anna.hellgren [at] med.lu.se

About the event

Time: 
27 January 2021 12:00 to 13:00
Location: 
Online/zoom
Contact: 
anna.hellgren [at] med.lu.se

Kajsa M Paulsson

Faculty of Medicine, Lund University, Box 117, 221 00 

Phone: +46 46 222 4167

Email: kajsa_m [dot] paulsson [at] med [dot] lu [dot] se